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KMID : 0352819870030010015
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Kosin Medical Journal
1987 Volume.3 No. 1 p.15 ~ p.22
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CHANGES IN ORGANIC ACID TRANSPORT SYSTEM IN CADMIUM INTOXICATED RAT KIDNEYS
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Kim, Y.K
Choi, J.K./Park, Y.S
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Abstract
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Kinetics of p-ammohippurate (PAFO transport was studied in rats treated with CdC 12 at a subcutaneous injection dose of 2rngC´.d/kgday. The Cdtreatrnent for 4^-16 days resulted in a marked reduction of the maximum rate of active PAH influx (Vmax) without any change in substrate affinity of the transport system (Km). The passive influx an j the efflux of PAH across the basolateral membrane and the rate of renal tissue oxygen consumption were not apparently attenuated in Cd-trraied animals.
These results indicate that the mechanism of impaired renal PAH excretion in Cd-treated animals is a loss of effective organic acid carriers in the basolateral membrane of proximal tubules.
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KEYWORD
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